The Metafilter Podcast usually features mathowie, jessamyn, and cortex, talking about the last month or so on the site (and whatever else is on their minds). It usually runs between an hour and two hours. You can find links to all the stuff discussed in an episode if you click into that episode's thread.
The mods don't create a transcript with the podcast, but there has been a volunteer effort to create transcripts for the podcasts on the MeFi Wiki. Podcasts with completed transcripts will have a little yellow "transcript" badge next to them on the main podcast page, or see this list of all the existing transcripts.